Molecular mechanisms of vancomycin resistance

Mechanisms of vancomycin resistance in Staphylococcus aureus

Vancomycin is a glycopeptide antibiotic used for the treatment of Gram-positive bacterial infections. Traditionally, it has been used as a drug of last resort; however, clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) strains with decreased susceptibility to vancomycin (vancomycin intermediate-resistant S. aureus [VISA]) and more recently with high-level vancomycin resist...

Molecular mechanisms involved in multidrug resistance in breast cancer therapy

Breast cancer is the most prevalent cancer in women. Chemotherapy is the main strategy in the treatment of this disease especially in the advanced form of the disease. Despite the recent progress in the development of new chemotherapy, the effectiveness of these drugs has dramatically reduced due to multidrug resistance. The phenotype of multidrug resistance (MDR) can occur through different me...

Molecular mechanisms of drug resistance.

Molecular Mechanisms of Antimicrobial Resistance

In the last 50 years bacteria have demonstrated a remarkable ability to develop and share resistance to every antibiotic that has been developed, often by quite unexpected mechanisms and much more readily than was originally predicted (Spratt, 1994). Antibiotic resistant bacteria can live and multiply in the presence of therapeutic levels of antibiotics. They can be resistant in their natural s...

Aspirin Resistance: Molecular Mechanisms & Techniques

Aspirin became a cornerstone in the treatment of coronary artery disease and widely used in the secondary prevention of vascular events. Aspirin resistance remains a poorly defined term though clinical definition is failure of the drug to prevent an atherothrombotic event despite the regular intake of appropriate doses is a relatively common problem. Various laboratory parameters assessing its ...